I think that generic engineering is a currently under-recognized issue. I think that in your rankings of global priority areas, there is a significant gap that leaves out this very important issue. To put it briefly, in same vein as bioweapon risk, this technology democratizes the ability to cause cataclysmic destruction analogous to nuclear weapon risk by orders of magnitude. For instance, small changes in bee genomes reducing reproducibility (as has been discussed in the context of mosquitos) could have as much damage to the global food system as the a nuclear winter would now. The social and economic repercussions of such an action, or of even an accidental, localized change in human or ecosystem genome, could be on par with that of climate change. It would be destabilizing and traumatic, and all of this is not to mention the changes that may begin to happen when human genetic engineering drastically increases wealth disparities, etc. I just think that Genetic Engineering Ethics/Legislation should be a priority area in the same way that AI is, and should be ranked pretty highly. Lots of under-appreciated spinoff effects.